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Lipid 03-135
Datasheet
Product identity and specifications
| Item | Information |
|---|---|
| Product | Lipid 03-135 |
| Catalog number | DCL0008 |
| CAS No. | Not confirmed |
| Molecular formula | C53H102N2O7 |
| Molecular weight | 879.41 |
| Purity specification | >95% by ELSD-HPLC |
Product description
Description & Application Lipid 03-135 is an ionizable lipid investigated for lipid nanoparticle delivery of mRNA encoding a CD19/CD3 bispecific T-cell engager developed by Abogen. In WO2024131874A1, its formulation showed the highest plotted serum antibody concentrations at 24 and 48 hours among five tested lipids after a single intravenous dose of mRNA1 in NOD/SCID mice. Research category: Ionizable lipids for in vivo T-cell engager In vivo T-cell engager research 03-135 LNPs delivered mRNA encoding a CD19/CD3 T-cell engager and supported circulating antibody expression in mice. Route: Intravenous. WO2024131874A1, Example 7, paragraph [0362], Figure 3B. RNA Delivery Ionizable lipids for in vivo T-cell engager RNA delivery research Cationic and ionizable lipids Featured lipid products
Formulation and performance
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Ordering
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References
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