Literature-reported formulation composition
Component: AO16 | Reported molar ratio: 2.50 | Normalized mol%: 2.44 | Role: Ionizable lipid
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Antioxidant lipid AO16
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: SM-102 | Reported molar ratio: 50.00 | Normalized mol%: 48.78 | Role: Ionizable lipid
Literature-reported formulation composition
Component: DSPC | Reported molar ratio: 10.00 | Normalized mol%: 9.76 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | Reported molar ratio: 38.50 | Normalized mol%: 37.56 | Role: Sterol
Literature-reported formulation composition
Component: DMG-PEG2000 | Reported molar ratio: 1.50 | Normalized mol%: 1.46 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported ratio sum | Reported molar ratio: 102.50 | Normalized mol%: 100.00 | Role: AO16 addition relative to SM-102
Reported observation
Literature-reported Antioxidant score at 0.05 mM 67% for AO16 LNPs versus 57% for the commercial control LNP Reactive species panel: O2−, ·OH, H2O2, ClO− and ONOO−; 5 mol% AO16 relative to SM-102 Supplementary Information p. 76, Supplementary Table 2.
Reported observation
Literature-reported Antioxidant score at 0.50 mM 32% for AO16 LNPs versus 37% for the commercial control LNP Same five-species panel at the higher challenge concentration Supplementary Information p. 78, Supplementary Table 2.
Reported observation
Literature-reported Reactive-species values at 0.05 mM O2− 87; ·OH 42; H2O2 72; ClO− 69; ONOO− 64 These are the source table values used to calculate the reported average score of 67. Supplementary Information p. 76, Supplementary Table 2.
Reported observation
What the source supports The cited article supports AO16 as an in vitro antioxidant-lipid screening candidate with the formulation and challenge conditions listed above. Nature Communications 2026;17:7166; DOI 10.1038/s41467-026-73512-3.
Reported observation
What is not assigned to AO16 AO12 was the lead selected for the paper's later regeneration, biodistribution and gene-editing experiments. Those AO12-specific animal results are not presented as AO16 product performance. Product-page evidence boundary.