DC82001 · Updated 28 October 2026
4A3-SC8
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 0.6816 mL | 0.3408 mL |
| 25 mg | 1.7039 mL | 0.8520 mL |
| 50 mg | 3.4079 mL | 1.7039 mL |
| 100 mg | 6.8157 mL | 3.4079 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| 4A3-SC8 | DC82001 | 1467.2 | 38.5 | 0.564872 |
| Cholesterol | DCD-041 | 386.65 | 30 | 0.115995 |
| DOPE | DC33634 | 744.03 | 30 | 0.223209 |
| DMG-PEG2000 | DC40169 | 2507 | 1.5 | 0.037605 |
Study DOPE variant: 4A3-SC8/cholesterol/DOPE/DMG-PEG2000 = 38.5:30:30:1.5 mol%. The phospholipid was varied in parallel groups. Reported 4A3-SC8:mRNA mass ratio = 23:1; this is not total lipid:mRNA or N/P.
Read the complete study conditions, biological results, tolerability and figures →
References
- Álvarez-Benedicto E et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomaterials Science 10, 549–559 (2022). DOI: 10.1039/D1BM01454D
- Xiong H et al. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. J Control Release 325, 198–205 (2020). DOI: 10.1016/j.jconrel.2020.06.030