DC82001 · Updated 28 October 2026

4A3-SC8

Product Datasheet

4A3-SC8 is an ionizable dendrimer lipid investigated for mRNA delivery. A systematic phospholipid study demonstrated formulation-dependent membrane fusion, intracellular delivery and liver-versus-spleen expression in mice.

CAS No.	1857340-78-3
Chemical Name	4A3-SC8
Synonyms	4A3 SC8，4A3SC8
SMILES	O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCCN(C)CCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)C CC(=O)OCCOC(=O)C(C)CSCCCCCCCC
Formula	C75H139N3O16S4
M.Wt	1,467.2
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Álvarez-Benedicto E et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomaterials Science 10, 549–559 (2022). DOI: 10.1039/D1BM01454D Xiong H et al. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. J Control Release 325, 198–205 (2020). DOI: 10.1016/j.jconrel.2020.06.030

Research evidence

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Specifications are catalog specifications, not batch test results.