E20
Version 1.f69f4b5f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | E20 |
| Synonyms | S-lipid E20, Lipid E20, E20 S-lipid |
| SMILES | CCCCCCCCC(CCCCCC)OC(=O)CCCCCCC(O)CN(CCCCCCC(=O)O)CC(O)CCCCCCC(=O)OC(CCCCCC)CCCCCCCC |
| Formula | C55H107NO8 |
| M.Wt | 910.46 |
| Purity | Not available |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Liang D, Qi Y, Han H, et al. Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles. Nature Nanotechnology. Published online September 8, 2026. |
E20 is a charge-switching ionizable S-lipid containing a tertiary amine, a carboxylic acid, two secondary alcohols and two branched ester-linked hydrophobic domains. The cited study formulated E20 into switchable nanoparticles (SNPs) for mRNA and plasmid-DNA delivery. Literature-reported E20 SNP data include an apparent pKa of 4.99 for becoming neutral, an N/P ratio of 4.1 in the reported four-component formulation, efficient hEPO mRNA expression after intravenous administration, low immunostimulatory activity in the reported models and activity in an intratracheal IL-22 mRNA acute-lung-injury study. All formulation and performance information shown below is literature-derived study evidence, not a product specification or a guarantee of reproducible LNP performance.
Specifications shown are product-page values, not batch test results.
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