AMG514
Version 1.4ecc2413 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | AMG514 |
| Synonyms | AMG-514, AMG 514 |
| SMILES | CCCCCCCCC(CCCCCC)C(=O)OCCCCCCC(O)CN1CCC2(CC1)CCN(CC(O)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)C2 |
| Formula | C56H108N2O6 |
| M.Wt | 905.49 |
| Purity | ELSD>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Gupta A, Das R, Reed K, et al. Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models. Nature Biotechnology. Published online 13 May 2026. |
AMG514 is a spirocyclic diamine ionizable lipid developed for spleen-biased mRNA delivery. In the cited mouse experiments, AMG514 LNPs produced approximately four-fold higher splenic reporter expression than a cKK-E12 comparator, transfected splenic dendritic cells and macrophages, and were evaluated for co-delivery of antigen and immune-remodeling mRNAs. The authors associated its approximately 7.5 apparent LNP pKa and serum- or plasma-derived protein-corona profile with the observed biodistribution, but did not establish a single causal targeting mechanism. All formulation and performance information shown below is literature-derived study evidence, not a product specification or a guarantee of reproducible LNP performance.
Specifications shown are product-page values, not batch test results.
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