DC Chemicals

DC68021 · Updated 28 October 2026

BIP-20

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg1.3713 mL0.6857 mL
25 mg3.4284 mL1.7142 mL
50 mg6.8567 mL3.4284 mL
100 mg13.7134 mL6.8567 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
BIP-20DC68021729.2128500.364606
DOPEDC33634744.03100.074403
CholesterolDCD-041386.6538.50.148860
DMPE-PEG2000Not uniquely mappedNot established1.5Not calculable from disclosed data

Selected downstream BiP-20 formulation: BIP-20/DOPE/cholesterol/DMPE-PEG2000 = 50:10:38.5:1.5 mol%. DMPE-PEG2000 is a PEG phospholipid, not DMG-PEG2000. Its commercial mapping and MW remain unassigned; N/P is not inferred. Source: formulation-optimization Results and Supplementary Fig. 5.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Jozić A, Le Roux C, Kim J, et al. In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery. Nature Biotechnology (2026). DOI: 10.1038/s41587-026-03022-6.
  2. Publisher article and Supplementary Information: main Figs. 1–3; supplementary formulation and editing studies.