Literature-reported formulation composition
Component: POPC | mol%: 6 | Role: Helper phospholipid
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MOCHOL GMP-like Quality
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DOPE | mol%: 24 | Role: Helper phospholipid
Literature-reported formulation composition
Component: CHEMS | mol%: 23 | Role: anionic_sterol_lipid
Literature-reported formulation composition
Component: MOCHOL | mol%: 47 | Role: ionizable_sterol_lipid
Literature-reported formulation composition
Component: Reported total | mol%: 100 | Role: Source values retained
Table 2
Item: Composition | Condition: NOV340 lipids | Reported result: POPC/DOPE/CHEMS/MOCHOL = 6/24/23/47 mol%
Table 2
Item: Release profile | Condition: pH 7.2-7.8 | Reported result: >75% RNA encapsulation; 50-150 nm; PDI <0.200; zeta < -30 mV
Table 2
Item: Frozen stability | Condition: -20 +/- 5 C | Reported result: No meaningful change reported through 6 months
Table 2
Item: Thermal stress | Condition: 72 h at 25 C / 40 C | Reported result: MOCHOL decreased 16% / 25% with cholesterol formation
Reported observation
Literature-reported Product particle specification 50-150 nm; PDI <0.200; zeta potential < -30 mV at pH 7.2-7.8 MTL-CEBPA release specification Paragraph [000613]
Reported observation
Literature-reported RNA encapsulation specification >75% RiboGreen total/free RNA method Paragraphs [000613]-[000615]
Reported observation
Literature-reported Process optimization yield About 50-60% CEBPA-51 concentration and pH experiments Paragraphs [000794]-[000805], Figs. 34-35
Reported observation
Literature-reported Cirrhosis-model outcomes Improved body weight, liver-function markers, ammonia, total protein, ascites and survival 1 mg/kg MTL-CEBPA started at week 8 or 11 Paragraphs [000826]-[000830], Figs. 36-38
Reported observation
pH-dependent loading MOCHOL is described as positively charged in the acidic RNA-loading phase (pKa 6.5); raising pH after vesicle formation produces the charge-converted final system. NOV340/MTL-CEBPA process · Paragraphs [000599]-[000604], [000794]
Reported observation
Storage degradation pathway Under 25-40 C stress, MOCHOL content fell while cholesterol increased; the other lipid excipients and total saRNA did not show significant changes in the described test. Single stability batch · Paragraphs [000822]-[000824]