DC67605 · Updated 28 October 2026
PyCB lipid
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.0759 mL | 0.5380 mL |
| 25 mg | 2.6898 mL | 1.3449 mL |
| 50 mg | 5.3797 mL | 2.6898 mL |
| 100 mg | 10.7594 mL | 5.3797 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| ALC-0315 | DC42537 | 766.27 | 35.6 | 0.272792 |
| PyCB lipid | DC67605 | 929.42 | 44.4 | 0.412662 |
| DSPC | DC57005 | 790.15 | 20 | 0.158030 |
ALC-0315/PyCB/DSPC = 35.6:44.4:20 mol%. Source: Supplementary Materials, optimized ThrCo LNP composition (p. 3). This formulation contains neither cholesterol nor PEG lipid. N/P and lipid:RNA mass ratio were not established; neither is inferred from the molar composition.
Read the complete study conditions, biological results, tolerability and figures →