Literature-reported formulation composition
Component: ARV-T1 | mol%: 50 | Role: Ionizable lipid
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ARV-T1
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DSPC | mol%: 10 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | mol%: 38.5 | Role: Sterol
Literature-reported formulation composition
Component: DMG-PEG2000 | mol%: 1.5 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported total | mol%: Not reported | Role: Source values retained
Reported observation
Literature-reported In-vitro mRNA protein expression Higher than SM-102; catalog summary reports approximately 7-fold higher expression HEK-293T cells, spike mRNA-LNP · SM-102 PDF p. 9, Fig. 3D; article summary.
Reported observation
Literature-reported Luciferase expression duration Strong signal through 72 h, with approximately 50% of peak signal remaining at 72 h BALB/c mice, IM, 1 µg Luc mRNA, n=6 · SM-102 signal barely detectable at 72 h PDF p. 11, Fig. 5.
Reported observation
Literature-reported Binding antibody response >10-fold higher at 0.01 and 0.1 µg than SM-102; 0.1 µg ARV-T1 similar to 1 µg SM-102 BALB/c mice, prime day 1/boost day 21 · SM-102 PDF p. 12, Fig. 6B–C.
Reported observation
Literature-reported Neutralizing antibody response >10-fold higher at 0.01 and 0.1 µg than SM-102; 0.1 µg ARV-T1 comparable to 1 µg SM-102 Pseudotyped-virus neutralization, day 35 · SM-102 PDF p. 12, Fig. 6D.
Reported observation
Literature-reported In-vivo toxicity No abnormal blood biochemistry, histology or body-weight change reported BALB/c mice, two injections 3 weeks apart · SM-102 PDF p. 13, Fig. 7.
Reported observation
Storage stability At −20 °C for 12 weeks, particle size, PDI, zeta potential, EE and protein expression were not significantly different from −80 °C storage; 4 °C and longer storage altered some parameters. · PDF pp. 10 and 14, Fig. 4 and Discussion.