Tidal Lipid 40
Version 1.825cb576 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Tidal Lipid 40 |
| Synonyms | Tidal Lipid-40 |
| SMILES | CCCCCCCCC(CCCCCC)C(=O)OCCCC(=O)OCC(COC(=O)CCCOC(=O)C(CCCCCC)CCCCCCCC)N(CCCCN(C)C)C(=O)CCC(=O)OC(CCC)CCCCCC |
| Formula | C63H118O11N2 |
| M.Wt | 1,079.64 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
Tidal Lipid 40is an ionizable cationic lipid engineered to deliver RNA with high precision to immune cells like macrophages. Based on Tidal Therapeutics' patent US 20250205169A1, Its pH-responsive design shifts from a +8 mV charge at pH 5.5 (enabling endosomal escape) to near-neutral at pH 7.4 (reducing off -target binding), ensuring efficient intracellular release while maintaining blood stability. In lipid nanoparticles, Lipid 40 achieves 65% transfection efficiency in human macrophages—surpassing benchmarks like ALC-0315—and protects >95% of RNA payloads from degradation. Critically, it maintains particle integrity after freeze-thaw cycles with minimal size drift (<5 nm) and excels in in vivo targeting, driving potent gene expression in tumor-associated macrophages while avoiding liver/spleen accumulation. This combination of precision delivery, stability, and low toxicity makes it ideal for immunotherapies, such as reprogramming M2 macrophages to anti-tumor M1 states.
Specifications shown are product-page values, not batch test results.
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