MeTis Lipid 5
Instructions for Use
Product information
MeTis Lipid 5 is an ionizable lipid featuring a pyrazole-based headgroup and biodegradable C8-ester twin tails developed by MeTis Pharmaceuticals (Patent CN118290339B). It demonstrated breakthrough in vivo efficacy (7.08E+10 photons, luciferase assay), surpassing MC3 lipid by 8.8-fold in systemic mRNA delivery. The molecule achieves optimal safety-profile (96.4% cell viability) and encapsulation efficiency (96.4%), forming LNPs of 108.9 nm (PDI 0.17) at N/P 6. Its ester-enabled rapid metabolization and balanced hydrophobicity position lipid 5 as a candidate for next-gen mRNA therapeutics.
| CAS No. | Not available |
| Chemical Name | MeTis Lipid 5 |
| Formula | C45H89NO5 |
| M.Wt | 870.36 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
Formulation & study context
Literature information refers to the cited study and its particular formulation. Administration routes are research context, not clinical instructions or a guarantee of performance.
A complete product-specific formulation has not been verified. No standard ratio is substituted.
| N/P ratio | Not reported in the verified record |
| Cargo | Not available in the verified record |
| Administration route | Not available in the verified record |
| Animal model | Not available in the verified record |
| Formulation process | Not available in the verified record |
N/P is the molar ratio of specified lipid nitrogen groups to nucleic-acid phosphate groups. A lipid:cargo mass ratio is a different quantity and must not be used as N/P.
Stock-solution preparation table
Calculated from the product-page molecular weight: 870.36 g/mol. Volumes are final solution volumes.
| Lipid mass | 1 mM | 5 mM | 10 mM |
|---|---|---|---|
| 10 mg | 11.489 mL | 2.298 mL | 1.149 mL |
| 25 mg | 28.724 mL | 5.745 mL | 2.872 mL |
| 50 mg | 57.447 mL | 11.489 mL | 5.745 mL |
| 100 mg | 114.895 mL | 22.979 mL | 11.489 mL |
| 250 mg | 287.237 mL | 57.447 mL | 28.724 mL |
Volume (mL) = mass (mg) × 1000 / [MW (g/mol) × concentration (mM)]. These are mathematical conversions, not measured solubility or validated solvent recommendations. Confirm solvent compatibility and the molecular weight of the exact material before use.
Open editable solution calculators →Handling & storage
Provided that storage conditions are as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 1 year.
Wherever possible, prepare and use solutions on the same day. If stock solutions must be prepared in advance, store them as aliquots in tightly sealed vials at -20°C. Generally, these will be usable for up to one month.
Before use, and prior to opening the vial, allow the product to equilibrate to room temperature for at least 1 hour.
References
Not available