PRODUCT DATASHEET · DC67552
MeTis Lipid 5
Version 1.b36b5565 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | MeTis Lipid 5 |
| Synonyms | MeTis Lipid-5 |
| SMILES | CCCCCCC(CCCCCC)CN1C=C(C(=O)OCCCCCCN(CCCCO)CCCCCCOC(=O)C2=CN(CC(CCCCCC)CCCCCC)N=C2)C=N1 |
| Formula | C45H89NO5 |
| M.Wt | 870.36 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
MeTis Lipid 5 is an ionizable lipid featuring a pyrazole-based headgroup and biodegradable C8-ester twin tails developed by MeTis Pharmaceuticals (Patent CN118290339B). It demonstrated breakthrough in vivo efficacy (7.08E+10 photons, luciferase assay), surpassing MC3 lipid by 8.8-fold in systemic mRNA delivery. The molecule achieves optimal safety-profile (96.4% cell viability) and encapsulation efficiency (96.4%), forming LNPs of 108.9 nm (PDI 0.17) at N/P 6. Its ester-enabled rapid metabolization and balanced hydrophobicity position lipid 5 as a candidate for next-gen mRNA therapeutics.
Specifications shown are product-page values, not batch test results.
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