ATX L2
Version 1.f5fe013a · 2026-09-13
| CAS No. | Not available |
| Chemical Name | ATX L2 |
| Synonyms | ATX-L2， ATXL2 |
| SMILES | CCCCCCC(CCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCC)CCCCCC)C(=O)OCCSSCCCN(C)C |
| Formula | C42H82O6N2S2 |
| M.Wt | 775.25 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Design and Evaluation of Biodegradable Self-Immolative Lipids for RNA Delivery-R Mukthavaram, A Sagi, H Hong, R Recatto… - Advanced healthcare materials |
L2 is a redox-responsive lipid engineered for ultra-potent siRNA delivery. With shorter hexyl (C6) tails and a carbamate linker, it demonstrates the fastest biodegradation (liver half-life: 2.6 days) among tested lipids. L2 achieves >80% FVII gene knockdown at just 0.01 mg/kg—surpassing both L1 and MC3 in siRNA potency. Its higher apparent pKa (6.90) enhances endosomal disruption, correlating with strong in vitro hEPO expression. While slightly less effective for mRNA than L1, L2’s unmatched siRNA silencing efficiency, rapid cytosolic self-immolation, and low cytotoxicity position it as a leading candidate for RNAi therapeutics targeting hepatic diseases.
Specifications shown are product-page values, not batch test results.
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