DC67520 · Updated 28 October 2026
nor-MC3
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.6285 mL | 0.8143 mL |
| 25 mg | 4.0713 mL | 2.0356 mL |
| 50 mg | 8.1425 mL | 4.0713 mL |
| 100 mg | 16.2851 mL | 8.1425 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| nor-MC3 | DC67520 | 614.06 | 20 | 0.120997 |
| Egg sphingomyelin (ESM) | Not uniquely mapped | Not established | 40 | Not calculable from disclosed data |
| Cholesterol | DCD-041 | 386.65 | 40 | 0.152374 |
| DMG-PEG2000 / PEG-DMG | DC40169 | 2507 | 1.5 | 0.037049 |
The selected study condition is R(B/I)=4. Ratios 20:40:40:1.5 are relative molar parts and sum to 101.5, not 100%. The calculator normalizes parts. ESM is a mixture with no single assigned MW here. DMG-PEG2000 uses the DC Chemicals catalog convention of 2507. Study NanoLuc N/P=6; not a mass ratio.
Read the complete study conditions, biological results, tolerability and figures →
References
- Cheng MHY et al. Liposomal lipid nanoparticles for extrahepatic delivery of mRNA. Nature Communications 16, 4135 (2025). DOI: 10.1038/s41467-025-58523-w.
- Supporting Information: Table S1 and Figures S2-S13.
- Related reference: Arnold D et al. nor-MC3 and nor-KC2: cationic ionizable lipids for the delivery of therapeutic nucleic acids. RSC Pharmaceutics 3, 654-658 (2026). DOI: 10.1039/D5PM00350D.