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DC67451 · Updated 24 October 2026

9C-SCC-10
Literature records

Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.

Table 1

System: Uncomplexed 9C-SCC-10 LNP | Composition / molar ratio: The supplied SI refers to earlier ethanol-dilution procedures; a complete formulation ratio for the uncomplexed screening arm is not explicitly restated. | N/P: Not reported | Reported context: Liver-biased Fluc mRNA expression; apparent LNP pKa 6.42

Table 1

System: Zn-9C-SCC-10 original LNP | Composition / molar ratio: Zn-9C-SCC-10 / DOPE / cholesterol / DMG-PEG2000 = 15:15:30:3 parts | N/P: Not reported | Reported context: Original metal-coordinated formulation; apparent LNP pKa 7.85

Table 1

System: Zn-9C-SCC-10 optimized LNP | Composition / molar ratio: Zn-9C-SCC-10 / DOPE / cholesterol / DMG-PEG2000 = 30:15:30:3 parts | N/P: Not reported | Reported context: Optimized formulation; apparent LNP pKa 7.89

Table 2

Component: Zn-9C-SCC-10 | MW: Not established | Raw molar parts: 15 | Calculated mol%: 23.8095 | µmol at 10 µmol total: 2.3810 | Calculated mass (mg): Requires confirmed complex MW

Table 2

Component: DOPE | MW: 744.05 | Raw molar parts: 15 | Calculated mol%: 23.8095 | µmol at 10 µmol total: 2.3810 | Calculated mass (mg): 1.7715

Table 2

Component: Cholesterol | MW: 386.65 | Raw molar parts: 30 | Calculated mol%: 47.6190 | µmol at 10 µmol total: 4.7619 | Calculated mass (mg): 1.8412

Table 2

Component: DMG-PEG2000 | MW: 2507 | Raw molar parts: 3 | Calculated mol%: 4.7619 | µmol at 10 µmol total: 0.4762 | Calculated mass (mg): 1.1938

Table 3

Component: Zn-9C-SCC-10 | MW: Not established | Raw molar parts: 30 | Calculated mol%: 38.4615 | µmol at 10 µmol total: 3.8462 | Calculated mass (mg): Requires confirmed complex MW

Table 3

Component: DOPE | MW: 744.05 | Raw molar parts: 15 | Calculated mol%: 19.2308 | µmol at 10 µmol total: 1.9231 | Calculated mass (mg): 1.4309

Table 3

Component: Cholesterol | MW: 386.65 | Raw molar parts: 30 | Calculated mol%: 38.4615 | µmol at 10 µmol total: 3.8462 | Calculated mass (mg): 1.4871

Table 3

Component: DMG-PEG2000 | MW: 2507 | Raw molar parts: 3 | Calculated mol%: 3.8462 | µmol at 10 µmol total: 0.3846 | Calculated mass (mg): 0.9642

Table 4

Original formulation example: Zn-9C-SCC-10 | Reported stock / volume: 16 mg/mL in DMF; 5 µL | Calculated lipid mass: 80 µg

Table 4

Original formulation example: DOPE | Reported stock / volume: 5 mg/mL in ethanol; 7.5 µL | Calculated lipid mass: 37.5 µg

Table 4

Original formulation example: Cholesterol | Reported stock / volume: 10 mg/mL in ethanol; 3.9 µL | Calculated lipid mass: 39 µg

Table 4

Original formulation example: DMG-PEG2000 | Reported stock / volume: 5 mg/mL in ethanol; 5 µL | Calculated lipid mass: 25 µg

Table 5

Endpoint: Relative organ Fluc expression, comparison S7a | Uncomplexed 9C-SCC-10: Liver 95.7% | Zn-9C-SCC-10: Lung 96.5% | Conditions / interpretation: Relative expression among measured major organs, not injected-dose recovery or transfected-cell percentage.

Table 5

Endpoint: Relative organ Fluc expression, comparison S7b/S7c | Uncomplexed 9C-SCC-10: Liver 96.0% | Zn-9C-SCC-10: Lung 97.0% | Conditions / interpretation: Separate figure comparisons; values are retained separately. General Fluc method: intravenous dosing, 6 h; exact screening dose assignment not resolved from the supplied SI.

Table 5

Endpoint: Apparent LNP pKa | Uncomplexed 9C-SCC-10: 6.42 | Zn-9C-SCC-10: 7.85 original; 7.89 optimized | Conditions / interpretation: TNS fluorescence titration; a formulation-dependent apparent pKa, not an intrinsic molecular pKa.

Table 6

Formulation: Zn-9C-SCC-10 | Lung share of organ Fluc signal: 97% | Study conditions: BALB/c mice; Fluc mRNA; intravenous 0.2 mg/kg; 6 h; n = 3

Table 6

Formulation: 4A3-SC-10 + 50% DOTAP SORT | Lung share of organ Fluc signal: 79% | Study conditions: Same comparison, SI Fig. S17

Table 6

Formulation: 4A3-SCC-10 + 50% DOTAP SORT | Lung share of organ Fluc signal: 91% | Study conditions: Same comparison, SI Fig. S17

Table 6

Formulation: MC3 + 50% DOTAP SORT | Lung share of organ Fluc signal: 65% | Study conditions: Same comparison, SI Fig. S17

Table 7

Lung cell population: Epithelial | Reported reporter-positive proportion: 43% | Experiment: Zn-9C-SCC-10 LNP; Cre mRNA; Ai9 mice; intravenous 0.2 mg/kg; 48 h; n = 2

Table 7

Lung cell population: Endothelial | Reported reporter-positive proportion: 61% | Experiment: Same experiment

Table 7

Lung cell population: Immune | Reported reporter-positive proportion: 2% | Experiment: Same experiment

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