9C-SCC-10
Datasheet

Product identity and specifications

Product description

Product overview Description & Application 9C-SCC-10 is a biodegradable ionizable lipid with a nine-membered triaza crown-like headgroup and three disulfide-containing hydrophobic arms. In the cited mouse study, LNPs containing uncomplexed 9C-SCC-10 showed liver-biased mRNA-derived expression and an apparent LNP pKa of 6.42. Coordination with zinc produced the distinct Zn-9C-SCC-10 system, which shifted expression toward the lung. DC67451 refers to the uncomplexed lipid; the zinc-coordinated formulation is described separately in the literature analysis. RNA Delivery Lung delivery Extrahepatic delivery Cationic and ionizable lipids Featured lipid products Liver delivery

Handling guidance

Handling guidance Shipping, storage and sampling How is the lipid shipped, and how should I store it? We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. Solution shelf life is not established for this product; use a validated solvent and aliquoting procedure. Keep sealed and protected from light. Avoid repeated thaw cycles for best results. Pure lipid or solution — which should I choose? Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed. How should I measure a small amount of oily or viscous lipid? Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first. Can you support formulation optimization and scale-up? Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows. Does this product contain coordinated zinc? DC67451 is uncomplexed 9C-SCC-10. Zinc coordination is a separate preparation in the cited study; its lung-delivery data do not describe the uncomplexed lipid. Avoid unvalidated reducing conditions because the structure contains disulfide linkages. Product-specific stock-solution stability has not been established.

Formulation and performance

Read the complete formulation, component quantities, experimental observations and evidence limits.

Search the retained literature tables and observations.

Ordering

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References

• DOI: 10.1021/jacs.4c14500