PRODUCT DATASHEET · DC65328
AA-T3A-C12
Product Datasheet
Version 1.c4012f0a · 2026-09-15
| CAS No. | Not available |
| Chemical Name | AA-T3A-C12 |
| Synonyms | AAT3AC12， AA T3A C12 |
| SMILES | OC(CCCCCCCCCC)CN(CC(O)CCCCCCCCCC)CCCN(CCCNC(C1=CC=C(OC)C=C1)=O)CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC |
| Formula | C65H126N4O6 |
| M.Wt | 1,059.72 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Han X, Gong N, Xue L, et al. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nature Communications. 2023;14:75. |
AA-T3A-C12 is an anisamide-tethered ionizable lipidoid containing a T3A polyamine core and four C12 epoxide-derived tails. In a four-component siRNA LNP, the anisamide group promoted sigma-receptor-dependent uptake by activated fibroblasts. In CCl4-induced liver fibrosis in mice, intravenous AA-T3A-C12/siHSP47 LNP reduced HSP47 and collagen deposition relative to the PBS disease control. These literature results apply to the cited formulation and do not establish performance of the neat lipid alone.
Specifications shown are product-page values, not batch test results.
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