AA-T3A-C12
Version 1.4829aaa8 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | AA-T3A-C12 |
| Synonyms | AAT3AC12， AA T3A C12 |
| SMILES | OC(CCCCCCCCCC)CN(CC(O)CCCCCCCCCC)CCCN(CCCNC(C1=CC=C(OC)C=C1)=O)CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC |
| Formula | C65H126N4O6 |
| M.Wt | 1,059.72 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis-Nature Communications volume 14, Article number: 75 (2023) |
AA-T3A-C12 is a leading anisamide-tethered lipidoid (AA-lipidoid) identified through a combinatorial library screening for targeted RNA delivery to activated fibroblasts, offering a promising approach to treat liver fibrosis.AA-T3A-C12 is a leading anisamide-tethered lipidoid (AA-lipidoid) identified through a combinatorial library screening for targeted RNA delivery to activated fibroblasts, offering a promising approach to treat liver fibrosis. It is synthesized via a one-pot, two-step modular method that combines anisamide—a ligand for sigma receptors overexpressed on activated hepatic stellate cells (HSCs)—with a T3A polyamine core and C12 epoxide tails, enabling efficient siRNA encapsulation in lipid nanoparticles (LNPs). In vitro, AA-T3A-C12 LNPs exhibit enhanced cellular uptake and gene silencing in activated fibroblasts, dependent on sigma receptor binding, as confirmed by haloperidol blockade studies, and outperform non-targeted analogs and the FDA-approved MC3 LNPs in fibroblast selectivity.In a mouse model of CCl4-induced liver fibrosis, AA-T3A-C12/siHSP47 LNP achieves approximately 65% knockdown of heat shock protein 47 (HSP47), a key fibrotic target, leading to significant reduction in collagen deposition and fibrosis alleviation, with a good safety profile and no exacerbation of liver injury.
Specifications shown are product-page values, not batch test results.
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