Lipid A33-D268
Version 1.765e4d59 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid A33-D268 |
| Synonyms | Lipid A33 D268 |
| SMILES | CCCCCCCCC(CCCCCC)C(=O)OCCCN(CCCOC(=O)C(CCCCCC)CCCCCCCC)CC1=CNC(N)=N1 |
| Formula | C42H80O4N4 |
| M.Wt | 705.13 |
| Purity | 98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
A33-D268 is an ionizable lipid derived from a 2-aminoimidazole (AM) core, featuring an asymmetric hydrophobic tail structure designed to optimize mRNA interactions. Selected as the top candidate from a 21-lipid library through molecular dynamics (MD) simulations, it demonstrated superior performance: low root mean square deviation (RMSD) and the smallest radius of gyration (Rg), indicating tight mRNA compaction, alongside moderate electrostatic energy and above-average hydrogen bonding for stable encapsulation. Formulated into LNPs, it achieves efficient muscle-specific transfection post-intramuscular injection, rivaling commercial ALC-0315 LNPs. Crucially, it exhibits 29-fold lower hepatic off-target expression, attributed to its inability to leverage serum protein coronas for liver tropism.
Specifications shown are product-page values, not batch test results.
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