DC Chemicals

DC60855 · Updated 28 October 2026

4A3-SC7

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg0.7087 mL0.3543 mL
25 mg1.7717 mL0.8859 mL
50 mg3.5434 mL1.7717 mL
100 mg7.0868 mL3.5434 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
4A3-SC7DC608551411.0715.040.212225
DOPEDC33634744.0323.040.171425
CholesterolDCD-041386.6538.720.149711
DMG-PEG2000DC4016925073.20.080224
4A3-Cit (Cit Liver SORT lipid)Not uniquely mappedNot established20Not calculable from disclosed data

Lead ABE liver formulation #12, Supplementary Table 3 (printed p.28; PDF p.29): 15.04:23.04:38.72:3.2:20 mol%; total lipid:RNA = 20:1 by mass. 4A3-Cit has not been uniquely mapped to a catalog product/MW, so its mass and the total mass percentage remain unassigned. N/P is not inferred.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Kim M, Song ES, Chen JC et al. Dual SORT LNPs for multi-organ base editing. Nature Biotechnology 44, 578–586 (2026); online 2 June 2025. DOI: 10.1038/s41587-025-02675-z.
  2. Supplementary Information: Figs. 1, 11–14; Tables 1–3 and additional methods.