DC Chemicals

DC60793 · Updated 28 October 2026

LUMI6

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Unopened pure lipid: −20 °C, up to 1 year. Follow batch expiry / retest information.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg1.2164 mL0.6082 mL
25 mg3.0411 mL1.5206 mL
50 mg6.0822 mL3.0411 mL
100 mg12.1644 mL6.0822 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
LUMI6DC60793822.07300.246621
DOTAPNot uniquely mappedNot established39Not calculable from disclosed data
CholesterolDCD-041386.65300.115995
DMG-PEG2000DC40169250710.025070

Final article STAR Methods: ionizable lipid / DOTAP / cholesterol / DMG-PEG2000 = 30:39:30:1 mol% for intratracheal experiments unless otherwise stated. DMG-PEG2000 MW is 2507. DOTAP counterion/catalog identity is not sufficiently specified for an exact mass assignment and remains blank. Neither N/P nor total lipid:RNA mass ratio is assigned.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Xu Y, Cui H, Pang K et al. LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery. Cell 189, 1620–1635.e25 (2026). DOI: 10.1016/j.cell.2026.01.012.
  2. Author publication page: final-publication PDF, STAR Methods and supplementary figures.