200Oi10
Version 1.63958ffd · 2026-09-13
| CAS No. | Not available |
| Chemical Name | 200Oi10 |
| Synonyms | 200,Oi,10， 200Oi,10 |
| SMILES | CC(C)CCCCCCCOC(=O)CCN(CCC(=O)OCCCCCCCC(C)C)CCN(CCC(=O)OCCCCCCCC(C)C)CCN1CCN(CCN(CCC(=O)OCCCCCCCC(C)C)CCC(=O)OCCCCCCCC(C)C)CC1 |
| Formula | C75H145O10N5 |
| M.Wt | 1,277.01 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies-J Control Release. 2024 Sep 18;375:366388. |
200Oi10 is a highly potent, biodegradable ionizable lipidoid optimized for targeted mRNA delivery, with its organ tropism dynamic to the route of administration. Under intravenous injection, it demonstrates an extraordinary 97.7% liver specificity mediated by endogenous ApoE binding. Strikingly, shifting to intraperitoneal injection redirects its tropism, yielding up to 46.4% pancreatic targeting, which can be further boosted when co-formulated with DOTAP. Featuring ester-conjugated cleavable tails, 200Oi10 guarantees rapid metabolic clearance and negligible tissue accumulation toxicity, making it an exceptional candidate for localized pancreatic therapy and efficient hepatic gene delivery.
Specifications shown are product-page values, not batch test results.
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