DC60510 · Updated 28 October 2026
Iso-A11B5C1
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.5103 mL | 0.7552 mL |
| 25 mg | 3.7759 mL | 1.8879 mL |
| 50 mg | 7.5517 mL | 3.7759 mL |
| 100 mg | 15.1035 mL | 7.5517 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| Iso-A11B5C1 | DC60510 | 662.1 | 60 | 0.397260 |
| DOPE | DC33634 | 744.03 | 10 | 0.074403 |
| Cholesterol | DCD-041 | 386.65 | 29 | 0.112128 |
| C14-PEG2000 (14:0 PEG2000 PE) | Not uniquely mapped | Not established | 1 | Not calculable from disclosed data |
Optimized molar composition = 60:10:29:1; ionizable lipid:mRNA = 10:1 by weight. The SI identifies 14:0 PEG2000 PE as the PEG lipid. Its exact commercial product mapping and molecular weight are not assigned here. This is not DMG-PEG2000; total mass fractions remain uncalculated until its molecular weight is specified. N/P was not reported.
Read the complete study conditions, biological results, tolerability and figures →