DC60478 · Updated 27 October 2026
ALC-0366
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.3808 mL | 0.6904 mL |
| 25 mg | 3.4521 mL | 1.7260 mL |
| 50 mg | 6.9042 mL | 3.4521 mL |
| 100 mg | 13.8083 mL | 6.9042 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Reported mg/mL | Calculated mass % |
|---|---|---|---|---|
| ALC-0366 | DC60478 | 724.2 | 10.64 | 54.90% |
| ALC-0159 | DC52020 | Not established | 1.35 | 6.97% |
| DSPC | DC57005 | 790.15 | 2.43 | 12.54% |
| Cholesterol | DCD-041 | 386.65 | 4.96 | 25.59% |
Table 2 reports mass concentrations, not molar percentages. RNA drug substance is 1.0 mg/mL. Calculated total lipid is 19.38 mg/mL, giving total lipid:RNA 19.38:1 by mass. An exact ALC-0159 molecular-weight convention is not supplied, so an exact molar conversion is not asserted.
Read the complete study conditions, biological results, tolerability and figures →