Literature-reported formulation composition
Component: C24 | mol%: 48 | Role: Ionizable lipid
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LIPID C24
Literature records
Search the tables and observations reproduced from the product literature guide. Rows may represent measurements, recipes or experimental context; they are not all independent experiments.
Literature-reported formulation composition
Component: DSPC | mol%: 13 | Role: Helper phospholipid
Literature-reported formulation composition
Component: Cholesterol | mol%: 37 | Role: Sterol
Literature-reported formulation composition
Component: DMG-PEG2000 | mol%: 2 | Role: PEG lipid
Literature-reported formulation composition
Component: Reported total | mol%: 100 | Role: Source values retained
Table 3
Experiment: Reporter expression | Condition: 0.5 microgram mRNA IM; 4 h | Reported result: Approximately 4-fold MC3 at muscle
Table 3
Experiment: Local histology | Condition: 5 micrograms mRNA; 24 h; n=3 | Reported result: Less injection-site inflammation than MC3 in this study
Table 3
Experiment: K18-hACE2 challenge | Condition: 0.25 microgram S2P; survival n=3 | Reported result: 3/3 followed mice survived
Table 3
Experiment: Short-term storage | Condition: PBS; 14 days | Reported result: Bioactivity stable at 4 C; 20-40% decrease at room temperature
Reported observation
Literature-reported TNS apparent pKa 6.77 C24 LNP; MC3 comparator 6.55 PDF Results and Fig. 1
Reported observation
Literature-reported Zeta-potential fit pKa / isoelectric point 5.21 / 6.12 Separate electrokinetic titration; not interchangeable with TNS pKa PDF Results and Fig. 1
Reported observation
Literature-reported RiboGreen-inaccessible mRNA 68% C24 LNP; MC3 79%; not labeled as definitive EE PDF Results and Fig. 1
Reported observation
Literature-reported Muscle luciferase expression Approximately 4-fold MC3 0.5 microgram mRNA IM; 4 h PDF Results and Fig. 2
Reported observation
Literature-reported Pseudovirus neutralization Approximately 10-fold MC3 after boost 0.25-1 microgram S2P mRNA doses PDF Results and Fig. 4
Reported observation
Literature-reported Challenge protection 3/3 followed mice survived at 0.25 microgram K18-hACE2; initial n=5, two animals/group used for day-5 lung titers PDF Fig. 5 legend
Reported observation
Liver off-target reporter signal At 5 micrograms mRNA, liver signal was reported as approximately sixfold lower than MC3 (p=0.051). BALB/c IM reporter study · PDF Results and Fig. 2
Reported observation
Lung viral titers C24 at 0.5 microgram eliminated detectable lung infection in the two animals assessed on day 5; MC3 did not completely eliminate infection even at 1 microgram. K18-hACE2 challenge; n=2 for lung titers · PDF Fig. 5
Reported observation
RNA integrity mRNA integrity was retained for at least 19 days at 4 C and declined more slowly for C24 than MC3 at higher storage temperatures. Study formulation in PBS · Supplementary stability figures