DC Chemicals

DC52025 · Updated 28 October 2026

SM-102

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg1.4081 mL0.7041 mL
25 mg3.5203 mL1.7602 mL
50 mg7.0406 mL3.5203 mL
100 mg14.0812 mL7.0406 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
SM-102DC52025710.1653500.355083
DSPCDC57005790.15100.079015
CholesterolDCD-041386.6538.50.148860
PEG2000 PE (14:0 in Methods)Not uniquely mappedNot established1.5Not calculable from disclosed data

SM-102/DSPC/cholesterol/PEG2000 PE = 50:10:38.5:1.5 mol%; N/P = 4. Methods identify 14:0 PEG2000 PE, whereas the Fig. 1 caption expands the name as a dioleoyl species. Because of this identity inconsistency, the PEG component is not assigned a catalog or molecular weight. It is not replaced by DMG-PEG2000 in this table or calculator.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Zhang L, et al. Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability. npj Vaccines 8, 156 (2023). DOI: 10.1038/s41541-023-00751-6.
  2. Full text, Figures 1–4 and Supplementary Figures 1–4.