DC52025 · Updated 28 October 2026

SM-102

Product Datasheet

SM-102 is an ionizable lipid used in LNP research for mRNA delivery. A controlled mouse study compared SM-102 with ALC-0315 and cKK-E12 using matched helper lipids, measuring intramuscular reporter expression, antibody responses, inflammatory markers and storage-dependent potency.

CAS No.	2089251-47-6
Chemical Name	SM-102
Synonyms	SM-102;SM 102;SM102
SMILES	O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O
Formula	C44H87NO5
M.Wt	710.1653
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Zhang L, et al. Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability. npj Vaccines 8, 156 (2023). DOI: 10.1038/s41541-023-00751-6. Full text, Figures 1–4 and Supplementary Figures 1–4.

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.