E4i-200
Version 1.d6b8211a · 2026-09-13
| CAS No. | Not available |
| Chemical Name | E4i-200 |
| Synonyms | E4i200， E4i 200 |
| SMILES | CC(C)CCCCC(O)CN(CCN1CCN(CCNC(CCN(CC(O)CCCCC(C)C)CC(CCCCC(C)C)N=O)C(O)CCCCC(C)C)CC1)CC(O)CCCCC(C)C |
| Formula | C55H114O5N6 |
| M.Wt | 939.55 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
E4i-200 is a branched ionizable lipid designed for efficient mRNA and CRISPR-Cas9 delivery. It features a 4-carbon (C4) lipid tail with an isopropyl (i) branch at the terminal position, enhancing its ability to disrupt endosomal membranes. The lipid is built around the 200 core, a polyamine structure (N1-(2-(4-(2-aminoethyl)piperazin-1-yl)ethyl)ethane-1,2-diamine), which facilitates mRNA encapsulation and delivery. E4i-200 excels in liver-targeted delivery, significantly improving mRNA translation and gene editing efficiency in vivo. In experiments, it outperformed linear lipids, achieving 1.5-fold higher liver luminescence compared to the gold standard C12-200. Its isopropyl branch promotes deeper membrane penetration, enhancing endosomal escape and cargo release. This lipid is particularly effective for hepatic gene editing, reducing target gene expression (e.g., TTR) by up to 90% in mouse models. Its modular design and low toxicity make it a promising candidate for mRNA-based therapies and CRISPR applications in the liver.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →