DC10800 · Updated 28 October 2026
DLin-MC3-DMA
Instructions for Use
Before use
Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.
Stock-solution planning
Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].
| Mass | 10 mM | 20 mM |
|---|---|---|
| 10 mg | 1.5574 mL | 0.7787 mL |
| 25 mg | 3.8934 mL | 1.9467 mL |
| 50 mg | 7.7868 mL | 3.8934 mL |
| 100 mg | 15.5737 mL | 7.7868 mL |
Literature formulation reference
| Component | DC Chemicals product | Molecular weight | Molar ratio | Mass at 1 µmol total lipid (mg) |
|---|---|---|---|---|
| DLin-MC3-DMA | DC10800 | 642.11 | 40 | 0.256844 |
| DSPC | DC57005 | 790.15 | 10 | 0.079015 |
| Cholesterol | DCD-041 | 386.65 | 40 | 0.154660 |
| PEG-C18 carbamate | Not uniquely mapped | Not established | 10 | Not calculable from disclosed data |
Initial screen: MC3/DSPC/cholesterol/PEG-C18 carbamate = 40:10:40:10 mol%. The source reports siRNA/total lipid = 0.05 by mass, equivalent to total lipid/siRNA = 20:1. This is not an N/P ratio. The PEG component is not DMG-PEG2000; its catalog mapping and molecular weight remain unassigned.
Read the complete study conditions, biological results, tolerability and figures →