DC Chemicals

DC10800 · Updated 28 October 2026

DLin-MC3-DMA

Product Datasheet

DLin-MC3-DMA (MC3) is an ionizable lipid studied for hepatic siRNA delivery. The 2012 study reported formulation-dependent Factor VII silencing in mice and transthyretin silencing in cynomolgus monkeys. Initial and optimized lipid compositions are documented separately.

CAS No.1224606-06-7
Chemical NameDLin-MC3-DMA
SynonymsDLinMC3DMA, DLin MC3 DMA
SMILESCCCCC/C=C\C/C=C\CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC/C=C\C/C=C\CCCCC
FormulaC43H79NO2
M.Wt642.11
Purity>95% by ELSD-HPLC
StoragePure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
Publication
  1. Jayaraman M et al. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo. Angew Chem Int Ed 51, 8529–8533 (2012). DOI: 10.1002/anie.201203263

Research evidence

Read detailed Formulation & Performance

Specifications are catalog specifications, not batch test results.