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Datasheet — U-510
DCL0016 · Updated 16 October 2026
Description:
U-510 is a three-tail Janus dendritic ionizable lipid containing an N-methyl tertiary amine, a hydroxypropyl head segment, an ester linker and three C8 ether-linked hydrophobic tails. In an intravenous luciferase-mRNA study in BALB/c mice, it showed a spleen-biased organ-expression profile within the U-509–U-512 series. The authors reported 52% spleen-targeting efficiency in the context of liver and spleen luminescence at 3 hours after 0.5 mg/kg mRNA; this is not a percentage of transfected spleen cells or injected dose. The U-510 LNP formulation had a reported size of 113 nm, PDI of 0.146, apparent LNP pKa of 6.38 and encapsulation efficiency of 87.88%. It supports preclinical evaluation of splenic mRNA expression rather than maximum whole-animal expression.
Chemical Information
| Parameter | Value |
|---|---|
| Catalog number | DCL0016 |
| Product name | U-510 |
| Aliases | U510; U 510; Janus lipid U-510 |
| Molecular formula | C39H79NO6 |
| Molecular weight | 658.06 g/mol |
| SMILES | CCCCCCCCOCC(COCCCCCCCC)(COCCCCCCCC)COC(=O)CCCCCN(C)CCCO |
| Purity / availability | >95% by ELSD-HPLC |
| CAS No. | Not available |
| Form | Neutral parent; no counterion or solvate depicted |
| Storage | Unopened pure lipid: −20 °C, up to 1 year. Follow the batch expiry / retest date. |
Handling:
Store the unopened product at −20 °C, protected from light and moisture, with the vial tightly sealed. The standard storage period is 1 year; follow the expiry or retest date on the supplied batch documentation. Allow the closed vial to reach room temperature before opening to avoid condensation.
We ship the pure lipid with ice packs, without ethanol. Prepare an ethanol stock solution when required. Gentle warming and brief sonication may assist dissolution; confirm complete dissolution at the intended concentration.
Prepare and use solutions on the same day wherever possible. If advance preparation is required, use a validated storage procedure and tightly sealed aliquots. A general solution shelf life is not assigned.
For small amounts of oily or viscous lipid, dissolve the entire pack and take volumetric aliquots. For example, dissolve 25 mg and adjust to a final volume of 1 mL to obtain 25 mg/mL; a 100 µL aliquot contains 2.5 mg.
References:
Liu C, Jiang Y, Xue W, Liu J, Wang Z, Li X. Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency. Bioorganic & Medicinal Chemistry. 2025;120:118080. doi:10.1016/j.bmc.2025.118080. Main article: 8 pages. Supporting Information: synthesis, Figs. S1–S50 and Table S1.