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Datasheet — U-503
DCL0015 · Updated 16 October 2026
Description:
U-503 is a Janus dendritic ionizable lipid with two tertiary amines, two hydroxyl groups, two ester linkers and six C10 alkyl tails connected to dendritic cores through ether bonds. It was identified alongside the C8-tail analogue U-502 as a leading intravenous mRNA-expression candidate in a 16-lipid study. In BALB/c mice given 0.5 mg/kg luciferase mRNA, U-503 produced a modestly higher 3-hour expression signal than the ALC-0315 comparator under the reported formulation conditions. Its LNP formulation had a size of 114 nm, PDI of 0.122, apparent LNP pKa of 6.31 and encapsulation efficiency of 89.36%. U-503 is a preclinical research candidate for systemic mRNA delivery and matched tail-length comparisons with U-502.
Chemical Information
| Parameter | Value |
|---|---|
| Catalog number | DCL0015 |
| Product name | U-503 |
| Aliases | U503; U 503; Janus lipid U-503 |
| Molecular formula | C89H178N2O12 |
| Molecular weight | 1468.41 g/mol |
| SMILES | CCCCCCCCCCOCC(COCCCCCCCCCC)(COCCCCCCCCCC)COC(=O)CCCCCN(CCCCCC(=O)OCC(COCCCCCCCCCC)(COCCCCCCCCCC)COCCCCCCCCCC)CCCN(CCO)CCO |
| Purity / availability | >95% by ELSD-HPLC |
| CAS No. | Not available |
| Form | Neutral parent; no counterion or solvate depicted |
| Storage | Unopened pure lipid: −20 °C, up to 1 year. Follow the batch expiry / retest date. |
Handling:
Store the unopened product at −20 °C, protected from light and moisture, with the vial tightly sealed. The standard storage period is 1 year; follow the expiry or retest date on the supplied batch documentation. Allow the closed vial to reach room temperature before opening to avoid condensation.
We ship the pure lipid with ice packs, without ethanol. Prepare an ethanol stock solution when required. Gentle warming and brief sonication may assist dissolution; confirm complete dissolution at the intended concentration.
Prepare and use solutions on the same day wherever possible. If advance preparation is required, use a validated storage procedure and tightly sealed aliquots. A general solution shelf life is not assigned.
For small amounts of oily or viscous lipid, dissolve the entire pack and take volumetric aliquots. For example, dissolve 25 mg and adjust to a final volume of 1 mL to obtain 25 mg/mL; a 100 µL aliquot contains 2.5 mg.
References:
Liu C, Jiang Y, Xue W, Liu J, Wang Z, Li X. Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency. Bioorganic & Medicinal Chemistry. 2025;120:118080. doi:10.1016/j.bmc.2025.118080. Main article: 8 pages. Supporting Information: synthesis, Figs. S1–S50 and Table S1.