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Lipid 01-1
Datasheet
Product identity and specifications
| Item | Information |
|---|---|
| Product | Lipid 01-1 |
| Catalog number | DCL0009 |
| CAS No. | Not confirmed |
| Molecular formula | C52H102N2O5 |
| Molecular weight | 835.40 |
| Purity specification | >95% by ELSD-HPLC |
Product description
Description & Application Lipid 01-1 is an ionizable lipid investigated for lipid nanoparticle delivery of mRNA encoding a CD19/CD3 bispecific T-cell engager developed by Abogen. In WO2024131874A1, 01-1-based LNPs supported serum antibody expression and were used in a Nalm6 leukemia model with human PBMCs. A single intravenous dose of mRNA1-LNPs reduced tumor bioluminescence relative to controls and the recombinant antibody regimen tested. Research category: Ionizable lipids for in vivo T-cell engager In vivo T-cell engager research 01-1 LNPs were used for CD19/CD3 T-cell engager expression and antitumor experiments in a human PBMC-engrafted Nalm6 leukemia model. Route: Intravenous. WO2024131874A1, Example 7, paragraphs [0362–0363], Figures 3B and 4A–4B. RNA Delivery Ionizable lipids for in vivo T-cell engager RNA delivery research Cationic and ionizable lipids Featured lipid products
Formulation and performance
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References
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