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MP2
Datasheet
Product identity and specifications
| Item | Information |
|---|---|
| Product | MP2 |
| Catalog number | DCL0007 |
| CAS No. | Not reported |
| Molecular formula | C74H132N2O14 |
| Molecular weight | 1273.87 |
| Purity specification | >95% by ELSD-HPLC |
Product description
Product overview Description & Application MP2 is a methylprednisolone-derived ionizable lipid with a steroidal headgroup and three acetal-containing C8 tails. In the cited study, MP2 was formulated with DOPE, cholesterol and DMG-PEG2k for rectal mRNA delivery to inflamed colonic tissue. The MP2 formulation produced about 15-fold higher colonic luciferase signal than the study's SM102 formulation in TNBS colitis mice. MP2 LNPs carrying IL-35 mRNA improved disease measures in acute and chronic mouse colitis models; mRNA delivery was also examined in ex vivo human colonic biopsies. These results describe the tested LNP formulations, not isolated lipid efficacy. RNA Delivery Colonic RNA delivery Extrahepatic delivery Cationic and ionizable lipids Featured lipid products
Formulation and performance
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Ordering
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