DC89101 · Updated 28 October 2026
C12-4 / A4 (C12-494)
Product Datasheet
C12-4, mapped to A4 / C12-494 in the cited paper and companion patent, is an ionizable lipid studied for placental mRNA delivery in pregnant mice. A4 LNPs delivered reporter mRNA to trophoblast, endothelial and immune-cell populations and were evaluated with VEGF-A mRNA for placental vascular effects. The studies are preclinical and do not establish reproductive safety or clinical efficacy.
| CAS No. | 2639634-71-0 |
| Chemical Name | C12-4 (Lipid A-4,Lipid F3,C12-494) |
| Synonyms | 2-Dodecanol, 1,1′-[[2-[2-[4-[2-[[2-[2-[bis(2- hydroxydodecyl)amino]ethoxy]ethyl](2- hydroxydodecyl)amino]ethyl]-1-piperazinyl] ethoxy]ethyl]imino]bis-,C12-4 (C12-494,Lipid A-4) ;C124， C12 4 |
| SMILES | CCCCCCCCCCC(O)CN(CCOCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CCN1CCN(CCOCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1 |
| Formula | C74H153N5O7 |
| M.Wt | 1,225.04 |
| Purity | >95% by ELSD-HPLC |
| Storage | Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication |
Research evidence
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Specifications are catalog specifications, not batch test results.