9(10)-Nitrooleate
Version 1.c489a4b4 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | 9(10)-Nitrooleate |
| Synonyms | 9(10)-Nitrated oleic acid |
| SMILES | OC(CCCCCCC/C([N+]([O-])=O)=C\CCCCCCCC)=O.OC(CCCCCCC/C=C([N+]([O-])=O)\CCCCCCCC)=O |
| Formula | C18H33NO4 |
| M.Wt | 327.46 |
| Purity | Not available |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
9(10)-Nitrooleate（NOA）is an endogenous nitrated fatty acid that functions as a highly efficient bioactive molecule. Its primary role is the specific inhibition of the STING protein, a key inflammatory signaling sensor within cells. When STING is aberrantly activated, it can trigger a severe inflammatory response, leading to cellular damage.Mechanistically, NOA acts as an electrophile, capable of covalently modifying specific cysteine residues on the STING protein, thereby effectively blocking its ability to activate downstream signaling pathways. This inhibitory action establishes NOA as a potent endogenous anti-inflammatory agent. In practical application, loading NOA into delivery systems, such as lipid nanoparticles, equips them with an intrinsic "molecular fire extinguisher." It significantly mitigates the acute inflammatory response triggered by delivered cargo, effectively transforming otherwise toxic delivery vehicles into safe platforms. The core value of NOA lies in its ability to provide exceptional safety without compromising the functional expression of therapeutic payloads, offering a crucial safeguard for achieving long-term treatments.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →