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Lipid A1B7C2

Version 1.eff3321d · 2026-09-13

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CAS No.Not available
Chemical NameLipid A1B7C2
SynonymsA1B7C2
SMILESn1cn(CCN(CC)CC)c(-c2cc(OCCCCC(=O)OCCCCCCCCCCCC)c(OCCCCC(=O)OCCCCCCCCCCCC)cc2)c1-c1ccc2ccccc2c1
FormulaC61H95N3O6
M.Wt966.7
Purity>98%
StorageOriginal product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month.
Shipping conditionShips from Shanghai. Pure lipid is stable during ice-pack transport.
PublicationMulticomponent Synthesis of Imidazole-Based Ionizable Lipids for Highly Efficient and Spleen-Selective Messenger RNA Delivery-Journal American Chemical Society (2024) 146 (22): 15085–15095.

A1B7C2 is an imidazole‑based ionizable lipid from the IMIL library. It features dimethylamino‑propyl imidazole head group, paired with B7 hydrophobic tails and C2 degradable ester linkers. LNPs assembled from A1B7C2 can effectively accumulate within the spleen after systemic administration. It mediates mRNA expression in splenic tissue, and is applied as a key control compound to investigate structure‑activity relationships for spleen‑targeted nucleic acid delivery.

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