A5-CE-C7-6
Version 1.e50f267c · 2026-09-13
| CAS No. | Not available |
| Chemical Name | A5-CE-C7-6 |
| Synonyms | Not available |
| SMILES | Not available |
| Formula | Not available |
| M.Wt | 689.7 |
| Purity | >98% by ELSD HPLC |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Carbonate-Bearing Ionizable Lipids for mRNA Delivery to the Spleen and Immune Cells[J]. Journal of the American Chemical Society, 2025. DOI: 10.1021/jacs.5c01389. |
A5-CE-C7-6 is an ionizable lipid engineered for spleen-targeted mRNA delivery, integrating a hydroxylated dual-amine core (A5) for enhanced mRNA binding and endosomal escape, a biodegradable carbonate ester linker (CE) enabling rapid hydrolysis (61% degradation in 24 h), and branched heptyl hydrophobic tails (C7-6) that optimize nanoparticle stability and spleen tropism. When formulated into cholesterol-free lipid nanoparticles (B-8 formulation), its unique architecture—combining hydroxyl groups for cellular uptake, carbonate-mediated biodegradability, and branched-chain fluidity—achieves unprecedented efficiency: low pKa (~6.0) minimizes liver accumulation while enabling 21% transfection of splenic NK cells, outperforming benchmark systems like MC3 SORT LNPs by >10-fold in spleen-specific delivery and establishing a new standard for in vivo immune cell engineering.
Specifications shown are product-page values, not batch test results.
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