KC-34(SPC-A9)
Version 1.8e4cafe2 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | KC-34(SPC-A9) |
| Synonyms | KC34, SPC-A9,KC 34 |
| SMILES | O=C1NC(CCC(=O)NCCN(CCCCCCCCC)CCCCCCCCC)C(=O)NC1CCC(=O)NCCN(CCCCCCCCC)CCCCCCCCC |
| Formula | C50H98N6O4 |
| M.Wt | 846.76 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Hatit M Z C, Lokugamage M P, Dobrowolski C N, et al. Substituting racemic ionizable lipids with stereopure ones improves the efficiency of lipid nanoparticles for mRNA delivery[J]. Nature Biomedical Engineering, 2023, 7(2): 134–146. |
KC-34 (SPC-A9) is a novel stereopure, diketopiperazine-based ionizable cationic lipid engineered to overcome traditional liver-restricted delivery, achieving balanced multi-organ mRNA transfection. Upon systemic intravenous administration, its precisely optimized chiral configuration allows the lipid nanoparticles (LNPs) to efficiently cross endothelial barriers and target the bone marrow, offering immense therapeutic potential for in vivo hematopoietic stem cell gene editing. Concurrently, KC-34 mediates robust and long-lasting protein expression in the spleen and lungs with minimal hepatic off-target toxicity. Its stable structure provides excellent biocompatibility and high in vivo tolerance, making it ideal for systemic, multi-dose mRNA therapies.
Specifications shown are product-page values, not batch test results.
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