Lipid GA-16
Version 1.4a464afd · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid GA-16 |
| Synonyms | Not available |
| SMILES | Not available |
| Formula | Not available |
| M.Wt | Not available |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
GA-16 is a novel ionizable lipid designed with an N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid) (HEPBS) core. Its key functional characteristic is enabling highly efficient, liver-tropic mRNA delivery through an ApoE-mediated yet Low-Density Lipoprotein Receptor (LDLR)-independent cellular uptake mechanism. When formulated in LNPs with the helper lipid DEPE, GA-16 achieves superior protein expression. More importantly, this uptake pathway bypasses the canonical LDLR dependency, making it a strategically valuable component for developing therapies targeting genetic liver diseases like familial hypercholesterolemia, where patients often have deficient LDLR function.
Specifications shown are product-page values, not batch test results.
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