Lipid Trp-L1-T4
Version 1.6083746f · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid Trp-L1-T4 |
| Synonyms | Trp-L1-T4, Trp L1 T4, Trp-L1T4, TLNP ionizable lipid |
| SMILES | CCCCCCCCCCCCCCN(CCCCCCCCCCCCCC)CCNC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 |
| Formula | C41H74N4O |
| M.Wt | 639.07 |
| Purity | >95% by ELSD-HPLC |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Zheng Z, Liu Y, Wang G, et al. In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis. Cell Stem Cell. 2026;33:589-604. |
Trp-L1-T4 is an L-tryptophan-derived ionizable lipid selected as the core lipid in the study's TLNP platform for self-amplifying RNA delivery to follicular helper T cells. The base TLNP formulation produced 59.8% GFP-positive primary Tfh cells under the reported in vitro conditions. In targeted variants, the authors combined CXCR5-antibody functionalization, Tfh-restricted RNA translation and, for in vivo work, Tween-20 modification to generate regulatory CAR-Tfh cells and evaluate a preclinical autoimmune-hepatitis model. These outcomes depend on the complete formulation, targeting ligand, RNA design and study conditions. All formulation and performance information shown below is literature-derived evidence, not a product specification or a guarantee of reproducible LNP performance.
Specifications shown are product-page values, not batch test results.
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