PRODUCT DATASHEET · DC68039
CHCha-10
Version 1.e0066ea7 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | CHCha-10 |
| Synonyms | CHCha10;CHCha 10 |
| SMILES | Not available |
| Formula | C76H142N6O10 |
| M.Wt | 1,300.0040 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
CHCha-10 is an amino acid-derived ionizable lipid engineered for pulmonary gene therapy. Its optimal surface charge (-0.126 mV) enables efficient mucus penetration, while a pKa of ~7.0 facilitates endosomal escape. Its unique conical structure promotes membrane fusion and mRNA release. In animal models, CHCha-10-based LNPs achieved highly efficient and specific editing of lung epithelial cells, particularly stem-like basal cells (~44%), with effects persisting through tissue renewal. It also demonstrated excellent efficacy and safety in ferrets, a model closely mimicking human lung physiology.
Specifications shown are product-page values, not batch test results.
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