DC68021 · Updated 28 October 2026

BIP-20

Product Datasheet

BIP-20 is an ionizable phosphoramidate lipid studied for liver-directed RNA delivery and genome-editing cargo delivery. Mouse studies compare reporter expression, TTR disruption and prime editing with benchmark LNPs, alongside an in vivo endolysosomal barcode assay.

CAS No.	Not available
Chemical Name	BIP-20
Synonyms	BIP20;BIP 20
SMILES	CCCCCCCCCCC(CCCCCCCC)COP(NCCN(C)C)(OCC(CCCCCCCC)CCCCCCCCCC)=O
Formula	C44H93N2O3P
M.Wt	729.2128
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Jozić A, Le Roux C, Kim J, et al. In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery. Nature Biotechnology (2026). DOI: 10.1038/s41587-026-03022-6. Publisher article and Supplementary Information: main Figs. 1–3; supplementary formulation and editing studies.

Research evidence

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Specifications are catalog specifications, not batch test results.