BIP-20
Version 1.91a929c9 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | BIP-20 |
| Synonyms | BIP20;BIP 20 |
| SMILES | CCCCCCCCCCC(CCCCCCCC)COP(NCCN(C)C)(OCC(CCCCCCCC)CCCCCCCCCC)=O |
| Formula | C44H93N2O3P |
| M.Wt | 729.2128 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Jozić A, Le Roux C, Kim J, et al. In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery. Nat Biotechnol. Published online March 11, 2026. doi:10.1038/s41587-026-03022-6 |
BiP-20 is a branched ionizable phospholipid identified as a lead compound for efficient hepatic mRNA delivery.BiP-20 is a novel, efficient, and safe liver-targeted LNP delivery vehicle. With an ideal pKa of 6.56, it achieves highly efficient liver targeting and endosomal escape primarily through the ApoE/LDL-R pathway. It demonstrates exceptional performance in gene editing at very low doses: for CRISPR-Cas9-mediated editing of TTR, a 10 μg dose achieved ~64% efficiency, which is 8-fold higher than the clinical benchmark lipid LP-01. In Prime Editing targeting the PCSK9 gene, its efficiency (4.30%) also significantly surpassed that of MC3, SM102, and LPO1. Furthermore, it mediates a 5.9-fold increase in hepatic protein expression compared to MC3. Safety assessments indicate it does not induce liver function abnormalities, showing strong therapeutic potential.
Specifications shown are product-page values, not batch test results.
Read Instructions for Use →