CL15F 6-4
Version 1.7a076425 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | CL15F 6-4 |
| Synonyms | CL15F 6 4 |
| SMILES | CCCCC(CCCC)C(=O)OCCCCCCC(O)(CCCCCCOC(=O)C(CCCC)CCCC)CCCCOC(=O)C1CCN(C)CC1 |
| Formula | C44H83O7N |
| M.Wt | 738.15 |
| Purity | ELSD-HPLC>95% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
CL15F 6-4 is a short-tail ionizable lipid from the piperidine-based CL15F series, characterized by its symmetric branched structure with a 6-carbon main chain and 4-carbon side chain. This specific tail length critically determines the lipid nanoparticle's (LNP) properties, resulting in larger particles with a high surface density of the phospholipid DSPC. This elevated DSPC density reduces interactions with serum proteins like ApoE, minimizing rapid liver clearance and shifting mRNA delivery preference towards the spleen. Consequently, CL15F 6-4 LNPs achieve efficient, endogenous spleen-targeted delivery, making them a highly promising candidate for enhancing vaccine efficacy by preferentially transfecting antigen-presenting cells without complex functionalization.
Specifications shown are product-page values, not batch test results.
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