Lipid 4A2-B8-PH
Version 1.ee01da04 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid 4A2-B8-PH |
| Synonyms | Lipid 4A2 B8 PH |
| SMILES | CCCCCC(CCC)CSCC(C)C(=O)OCCCSC(C)(C)SCCCOC(=O)CCN(CCCN(C)CCCN(CCC(=O)OCCCSC(C)(C)SCCCOC(=O)C(C)CSCC(CCC)CCCCC)CCC(=O)OCCCSC(C)(C)SCCCOC(=O)C(C)CSCC(CCC)CCCCC)CCC(=O)OCCCSC(C)(C)SCCCOC(=O)C(C)CSCC(CCC)CCCCC |
| Formula | C111H211O16N3S12 |
| M.Wt | 2,228.63 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
4A2-B8-PH is an optimally designed thioketal-incorporated biodegradable ionizable lipid (TBIL) for mRNA delivery to pancreatic ductal epithelial cells. It features a 4A2 headgroup with three tertiary amines, a biodegradable thioketal-based B8 linker, and a branched PH tail. The thioketal linker enables ROS-responsive degradation in the tumor microenvironment, enhancing endosomal escape and mRNA release. In vivo, 4A2-B8-PH LNPs achieve 98.3% pancreas-specific targeting after intraperitoneal administration, with a 218-fold improvement in delivery efficiency compared to previous benchmarks. It successfully transfects 30.5% of pancreatic ductal epithelial cells and induces complete tumor regression in orthotopic PDAC models via IL-12 mRNA therapy, demonstrating high efficacy and safety.
Specifications shown are product-page values, not batch test results.
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