PRODUCT DATASHEET · DC67633
Lipid KEL12
Version 1.5ad2a7fb · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid KEL12 |
| Synonyms | Lipid-KEL 12，Lipid KEL-12 |
| SMILES | CCCCCCCCCCC(=O)OCCCCCCC1(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)OCC(CCN(C)C)O1 |
| Formula | C49H95O6N |
| M.Wt | 794.30 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
(4S)-KEL12 is a novel, biodegradable ionizable lipid developed for advanced mRNA vaccine delivery. It was rationally designed by incorporating both a ketal group in the linker and ester segments in the hydrophobic tails, a dual-degradable strategy aimed at enhancing its safety profile. Through iterative optimization, (4S)-KEL12 was identified as a lead candidate with an optimal pKa value of approximately 6.78, which is crucial for efficient mRNA encapsulation and endosomal release.
Specifications shown are product-page values, not batch test results.
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