Lipid GL5
Version 1.0a941589 · 2026-09-13
| CAS No. | Not available |
| Chemical Name | Lipid GL5 |
| Synonyms | LipidGL5，Lipid-GL5,GL-5, GL 5 |
| SMILES | CCCCCCCC/C=C\CCCCCCCCCCCC(=O)OCCN(CCOC(=O)CCCCCCCCCCC/C=C\CCCCCCCC)C(=O)C1=CC=C(C(=O)NC(=N)N)N1 |
| Formula | C55H97O6N5 |
| M.Wt | 924.41 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
GL5 is an ionizable guanidine-based lipid nanoparticle (G-LNP) designed for superior mRNA delivery. Its guanidinocarbonyl-pyrrole (GCP) headgroup enables pH-responsive behavior and strong mRNA binding via bidentate hydrogen bonds. The cholesterol-free GL5-3 formulation forms compact, stable nanoparticles (~90-120 nm) that exhibit excellent spleen-targeting capability after intravenous injection.GL5-LNPs efficiently deliver mRNA to antigen-presenting cells (APCs), enhancing antigen presentation and T cell activation. In cancer immunotherapy models, GL5-based mRNA vaccines provided complete tumor protection and induced durable immune memory. The platform also enables mRNA delivery to other organs like the pancreas via different administration routes, demonstrating remarkable versatility and therapeutic potential.
Specifications shown are product-page values, not batch test results.
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