DC Chemicals

DC67601 · Updated 28 October 2026

Sanofi Lipid 15

Instructions for Use

Before use

Check the supplied lot number, batch COA, approved SDS, quantity and retest date. Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.

For small quantities of viscous or oily lipid, volumetric transfer can reduce weighing losses. Confirm solvent compatibility and solubility before preparing a stock; calculated volumes do not establish solubility.

Stock-solution planning

Volume (mL) = mass (mg) × 1000 / [molecular weight × concentration (mM)].

Mass10 mM20 mM
10 mg1.0576 mL0.5288 mL
25 mg2.6441 mL1.3220 mL
50 mg5.2882 mL2.6441 mL
100 mg10.5763 mL5.2882 mL

Literature formulation reference

ComponentDC Chemicals productMolecular weightMolar ratioMass at 1 µmol total lipid (mg)
Sanofi Lipid 15DC67601945.51490.463300
CholesterolDCD-041386.65390.150793
DSPCDC57005790.15100.079015
DPG-PEG2000Not uniquely mappedNot established2Not calculable from disclosed data

Base lipid blend: Lipid 15/cholesterol/DSPC/DPG-PEG2000 = 49:39:10:2 mol%. DPG-PEG is not DMG-PEG2000; 2507 is therefore not assigned to it. The reported N/P design range is 4–6. CD8-targeting VHH conjugate is introduced separately and is not represented as a fifth prefilled bulk-lipid percentage.

Read the complete study conditions, biological results, tolerability and figures →

References

  1. Lemgart VT et al. Reprogramming CD22 CAR-T cells in vivo using CD8-targeted mRNA-LNPs to treat hematological malignancies. Molecular Therapy 34 (2026). DOI: 10.1016/j.ymthe.2026.02.020