IAJD249
Version 1.9bfcac3a · 2026-09-13
| CAS No. | Not available |
| Chemical Name | IAJD249 |
| Synonyms | IAJD 249， IAJD-249 |
| SMILES | CCCCC(CC)COCC(COCC(CC)CCCC)(COCC(CC)CCCC)COC(CCCN1CCN(CCO)CC1)=O |
| Formula | C39H78N2O6 |
| M.Wt | 671.05 |
| Purity | >98% |
| Storage | Original product: up to 1 year under the storage conditions stated on the vial, kept tightly sealed. Stock solutions: aliquots at -20°C, generally up to one month. |
| Shipping condition | Ships from Shanghai. Pure lipid is stable during ice-pack transport. |
| Publication | Not available |
IAJD 294 is a single-component ionizable amphiphilic Janus dendrimer that autonomously coassembles with mRNA via simple injection into uniform monodisperse dendrimersome nanoparticles (DNPs, 85 nm diameter, PDI<0.2), eliminating complex multi-component formulations. Its optimized 3,5-benzoyl ester linkage and symmetric hydrophobic tails enable dual-organ targeting: Spleen: 2.97 × 10⁷ RLU (50% of total activity) Lymph nodes: 10⁶ RLU (10× higher than IAJD 87) through partial hydrophobic interdigitation (stabilizing DNPs for enhanced lymphatic uptake) and pKa ~6.5 (facilitating endosomal escape), validating constitutional isomerism for precision delivery.
Specifications shown are product-page values, not batch test results.
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